This time around I went full Arms until 40 for Mortal Strike, doing some dungeons but mostly grinding in the overworld.
In the past I’ve been more tank-oriented, and I’ve gone first Arms for Tactical Mastery (and usually Anger Management), and then Prot for 1pt Improved Shield Block and then Defiance, then Cruelty (Fury) and other damage/threat talents from there, then respeccing at 40 to choose a 31 pt talent.