I use exclusively mouse and keybinds in combat to the degree that I’m not really used to having to pay attention to exactly where my mouse cursor is in order to efficiently click on anything.
I have had to adjust my playstyle a lot for healing, where you have to mouseover, and for those mechanics that require you to quickly click on something (bombs on Underpin, for example).
Even my strafe and back keys are bound to buttons on my mouse, so my left hand is strictly keybinds.
I will click for some out-of-combat stuff that isn’t worthy of a keybind.