This might help, but maybe not, it might depend on how long your fingers are. But this is the only game I play with arrow keys instead of WASD. I bind everything to the numpad (minus, asterisk, even enter key is rebound) and mix it with CTRL or Shift modifiers. I only use the shift abilities for out of combat stuff, and that still leaves me 32 hotkeys within good reach. I also bind end, delete, page down, etc for some extra stuff.
I might be extreme though. I have binds to drink, and even /chicken.