by “grid mode to non-QWER” do you mean non-english? the default grid mode sets the spell hotkeys to ZXCV, if you want the spells on QWER you have to download a customkeys.txt file
And for Alt/Shift or Shift+Enter? You can change that in the Chat/Log screen by clicking F11 in-game, so that you dont have to hold Shift… not sure what else you would change it to though
Here is a guide for custom hotkeys, which includes some common grid alignments for English, German and French: