Game is missing files

Everytime I launch the game I get a “missing files” error message, then I have to uninstall and reinstall the game…the Blizzard repair doesn’t work- this happens every time actually play a game, whether online or just me against the computer- it doesn’t happen if i just login to the Battlenet screen, but leave before playing, it happens only when I actually play a game-does anybody have any ideas on how to fix this?

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Got an overzealous anti virus?
Maybe disable it while reinstalling.

Have you tried setting your installation folder as Read Only?