What is the White Box on left screen?

Recently an white box appears on my screen everytime when i click my M1 mouse buton in the game.
How to fix it please ?

That’s the Nvidia Reflex flash indicator, which was introduced in the latest patch. It can be disabled in-game by:

Options > Video > Nvidia Reflex > Flash Indicator > Disabled

Edit to clarify: Follow these steps inside of Overwatch, not Nvidia settings.

See this thread for details: