beams melt through everything pretty much
Lifeweaver if there’s an Ana, Zenyatta if no Ana. (On enemy team.)
Just focus her, those bubbles have hp and you can break them. Running away is not the answer. Zenyatta and/or Granny Ana help.
if she is low energy you can burst her down but if she is full or high energy then accept your fate (or run away if you can).