Alright so short and simple Nvidia was able to fix it.
The watered down solution for me was this:
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Use the Nvidia developer cleanup tool to remove any and all Nvidia software/ drivers.
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Install the fresh driver manually from the Nvidia driver home page. Be sure to know your exact GPU and select the correct model.
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When installing the driver manually, be sure to select “Custom Installation” and “Clean Install” as prompted.
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After the fresh driver is installed reboot the computer.
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Open the Nvidia Control Panel and under the 3D settings tree select “Configure Surround, PhysX”.
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Set the dropdown value to your GPU instead of auto or CPU.
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In the same 3D settings tree select “Manage 3D Settings”.
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Select the “Program Settings” tab and select the OW2 executable by clicking “add”.
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Set the graphics processor to “High Performance Nvidia Graphics Processor”.
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Start OW2 and if it does not open in the correct aspect ratio or resolution use the in game settings to fix this instead of ALT + ENTER or other windows shortcuts as that caused the game to crash.
Per Nvidia directly despite RTX A series/ Quadro cards being intended for professional use there is absolutely nothing that should prevent them from running any and all programs that can be run on their GeForce cousins. Nvidia also said the issue was purely driver/ GPU config related and the crashing when using Windows shortcuts such as ALT + ENTER is an issue Blizzard would need to look into.
I hope this is helpful, thank you Nicole.