There is a bit of a difference in for example
3 sense ingame and 1600 DPI
6 sense ingame and 800 DPI
I use mostly 5.20 and 800 DPI, would not go over 800 DPI because it just feels weird. But that is me.
Point is if you lower your DPI by 50%, do it also with ingame sense 50%. And you somewhat have the same.