Game settings keep resetting every launch. Can not save new settings while in game

This is really frustrating, and seems to be after the last patch

EVERY time I launch the game now, I have to rewatch the cinematic and all the video quality settings and such have all be set to default, like it was a new install.

While in game, I can not create a new hotkey profile, nor will any changes to those settings stick. So I cant EVER make a spell quickcast for example. Ill select it, but it just goes to default as soon as I go back to gameplay. Try to turn quickcast on for ALL spells, same thing.

Just reinstalled the game thinking that was it, no dice, same issue. I thought maybe the heroes of the storm folder in documents was read only, so selected it and made it all NOT that. No solution there.

I am out of ideas… what is going on?

Had the same problems. Let Windows Defender allow Hots to do what ever it wants and it worked for me.