Wouldn’t it be cool if there was a card that said at the start of the game:
… all cost of cards cannot be changed.
… all quests are dropped.
… can only gain one mana per turn.
… all players cannot make copies of any kind from any source.
… all hero powers can only be used once a turn, no matter what.
etc.
Start of game, all “discover” effects become “random card” effects.
Start of game, cards that would be cast when drawn are instead drawn normally.
Start of game, if a player would draw cards through a card effect, that player draws that many cards minus one (1).
Start of game, hero powers cost four (4).