Relocating Diablo Installation location

Does Diablo need to be uninstalled to change installation location from C drive to D drive or external (if it will run from there) ? C drive is SSD and over 80% full. D drive is HHD at 49% (mirrored) and external 85GB of 2TB. Been a long time since I relocated any installation directory on a PC, and used 3rd party application in the past. Running Win !! Home.