Oh I don’t doubt it is Blizzard and patch related…I did a search and this popped up
look through that in case someone found a solution.
I have a 3090ti and have had to troubleshoot at many patches and that is basically how I would start…lower settings till it stabilizes then work back up.
Try this also, it may help, in nVidia control panel Manage3d settings/Shader Cache Size…
Set that to something else. Hit apply, then set it back, and hit apply. What that will do is force the shader cache folder to refill.