Thank you for the feedback.
I run d4 on a 5800x3d with a 3090ti, in windows 10.
the difference we have, is your game using 22gb ram, and my game is running on 9…
What caused my friends constant crashes, was he was close to max usage, but i was not.
somehow it fixed my problem with random crashes tho =)
I guess you did all the things like enabled game mode in windows and such.
At this time nothing else comes to mind, but i let you know if some more solutions come to mind =) GL