I see the potential I am saying its just not realistic to remap 4 buttons for multiple inputs esp with the runewords as well. Most of this has to be automated to work.
PPL use teleport to move around quickly out of danger. Wormhole would be the most popular option by far. Other choices would have to be seriously op to counter. This is an issue with this system using it in combat. Best choices would become meta and then the dynamic part is gone. This is esp true taking your next part into play with runewords as you have more keys to hit. This has to be automatic. This is too many inputs to cast 1 skill.
Anyways I have said too much here. Good luck with more designs!