Possibly. That or the 50xx series GPU driver interaction with the CPU for some reason.
Do you have the following set in Windows?
- GPU Scheduling set to ON.
Do not use the nVidia Experience app, or whatever they are running these days.
(I never use their extra software, just the driver)
Have you tried disabling Direct Storage for Diablo IV? (potential drive interaction issue)
Open the battlenet launcher, find the gear cog next to the game’s play button. Click that, and go to game settings. Under here look for Command line arguments, and enable that.
In the box provided put the following command:
-disableds
Then save settings and try again.