Blizzard is not taking the anti modding route for D2R, unless they specifically say so by launch. They are restricting dll injection, as stated at Blizzcon. They didn’t say that they would support private servers however, which most of us already assumed from the get go, and was confirmed by Swiftkitten when senpai and greendude said they would not be converting their mod realms to D2R, since they technically are already breaking the rules with how they have their games to begin with.
Launch is not here yet. Once the game launches, modders will be able to take a look at what Blizz is allowing, and will be able to make their full, informed decisions there.