I’ve been lucky this Season 22 and have not experienced freezing in-game.
However, twice this Season, while playing on the Americas Region, I’ve had the game freeze on me when leaving the game and going to the Game Menu. The Menu animation continues, but the Start Game button, Game Settings button, and the Quick Join games available are grayed-out. See image below.
The only way I can correct this is to quit the game and relaunch. Once I do this I no longer have any issues… until the next time it happens. (Like I stated above, this is only the second time it’s happened to me this Season).