You didn’t say but… are you getting an error code ? or a crash ID ?
(A crash ID is that God-awful 30 something long hexadecimal code that the game sometime spurts out when it crashes).
If you are using a Razer mouse and/or a Razer keyboard, see the workaround here:
You should probably start your own topic if the above does not solve the issue… and provide a DxDiag as suggested above by Blizzard.