I found a method where the crash always take place in the exact same location.
Campaign mode at normal difficulty starting with the first quest.
Act 1 works with no problems or lags.
The game always crashes in Act 2 at the quest “Shadows in the Desert” after searching for the “Hidden Camps” on the Howling Plateau map.
I’ve tried many workarounds from the main thread.
None of them work for me.
Here the D3Debug.txt form the latest crash and my DxDiag.