I think I just solved this painful experience for myself in Windows 11. I had multiple crashes and freezes with D2R, even though ~20 other games ran perfectly.
- In Settings > System > Display > Graphics, I turned OFF this one option:
- Optimizations for windowed games
- In Settings > System > Display > Graphics > Advanced Graphics Settings, I turned both options OFF:
- Hardware-accelerated GPU scheduling
- Variable refresh rate
I would guess that turning off Hardware-accelerated GPU scheduling was the one that fixed it, but I didn’t test individually, and now that it’s working, I’ll leave it well alone.
Good luck!