Thank you for expanding on the topic. Most runewords are, indeed, unattractive and the most abundant weapon and armor types are underutilized.
Nerfing the game through class buffs and gear upgrades isn’t the way to go. Toning down meta builds and brings skill diversity is an amicable goal.
As for the most OP runewords, use them as as a gauge to where item power should be capped
I touched base on runewords ability to stack on staff mods here: